Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
Identifieur interne : 000016 ( Main/Exploration ); précédent : 000015; suivant : 000017Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
Auteurs : Philippe Gautret [France] ; Jean-Christophe Lagier [France] ; Philippe Parola [France] ; Van Thuan Hoang [Viêt Nam] ; Line Meddeb [France] ; Jacques Sevestre [France] ; Morgane Mailhe [France] ; Barbara Doudier [France] ; Camille Aubry [France] ; Sophie Amrane [France] ; Piseth Seng [France] ; Marie Hocquart [France] ; Carole Eldin [France] ; Julie Finance [France] ; Vera Esteves Vieira [France] ; Hervé Tissot Tissot-Dupont [France] ; Stéphane Honoré [France] ; Andreas Stein [France] ; Matthieu Million [France] ; Philippe Colson [France] ; Bernard La Scola [France] ; Véronique Veit [France] ; Alexis Jacquier [France] ; Jean-Claude Deharo [France] ; Michel Drancourt [France] ; Pierre Edouard Fournier [France] ; Jean-Marc Rolain [France] ; Philippe Brouqui [France] ; Didier Raoult [France]Source :
- Travel medicine and infectious disease [ 1873-0442 ]
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Association de médicaments (MeSH), Azithromycine (usage thérapeutique), Betacoronavirus (effets des médicaments et des substances chimiques), Charge virale (MeSH), Femelle (MeSH), France (MeSH), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (traitement médicamenteux), Jeune adulte (MeSH), Mâle (MeSH), Pandémies (MeSH), Partie nasale du pharynx (virologie), Pneumopathie virale (traitement médicamenteux), Projets pilotes (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Betacoronavirus.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Azithromycine, Hydroxychloroquine.
- virologie : Partie nasale du pharynx.
- Adulte, Adulte d'âge moyen, Association de médicaments, Charge virale, Femelle, France, Humains, Jeune adulte, Mâle, Pandémies, Projets pilotes, Sujet âgé, Sujet âgé de 80 ans ou plus.
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Azithromycin (therapeutic use), Betacoronavirus (drug effects), Coronavirus Infections (drug therapy), Drug Therapy, Combination (MeSH), Female (MeSH), France (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Male (MeSH), Middle Aged (MeSH), Nasopharynx (virology), Pandemics (MeSH), Pilot Projects (MeSH), Pneumonia, Viral (drug therapy), Viral Load (MeSH), Young Adult (MeSH).
- MESH :
- chemical , therapeutic use : Azithromycin, Hydroxychloroquine.
- geographic : France.
- drug effects : Betacoronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- virology : Nasopharynx.
- Adult, Aged, Aged, 80 and over, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Pandemics, Pilot Projects, Viral Load, Young Adult.
Abstract
BACKGROUND
We need an effective treatment to cure COVID-19 patients and to decrease virus carriage duration.
METHODS
We conducted an uncontrolled, non-comparative, observational study in a cohort of 80 relatively mildly infected inpatients treated with a combination of hydroxychloroquine and azithromycin over a period of at least three days, with three main measurements: clinical outcome, contagiousness as assessed by PCR and culture, and length of stay in infectious disease unit (IDU).
RESULTS
All patients improved clinically except one 86 year-old patient who died, and one 74 year-old patient still in intensive care. A rapid fall of nasopharyngeal viral load was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% of patients at Day5. Consequently patients were able to be rapidly discharged from IDU with a mean length of stay of five days.
CONCLUSION
We believe there is urgency to evaluate the effectiveness of this potentially-life saving therapeutic strategy at a larger scale, both to treat and cure patients at an early stage before irreversible severe respiratory complications take hold and to decrease duration of carriage and avoid the spread of the disease. Furthermore, the cost of treatment is negligible.
DOI: 10.1016/j.tmaid.2020.101663
PubMed: 32289548
PubMed Central: PMC7151271
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Binh</wicri:regionArea><wicri:noRegion>Thai Binh</wicri:noRegion></affiliation></author><author><name sortKey="Meddeb, Line" sort="Meddeb, Line" uniqKey="Meddeb L" first="Line" last="Meddeb">Line Meddeb</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Sevestre, Jacques" sort="Sevestre, Jacques" uniqKey="Sevestre J" first="Jacques" last="Sevestre">Jacques Sevestre</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, 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sortKey="Amrane, Sophie" sort="Amrane, Sophie" uniqKey="Amrane S" first="Sophie" last="Amrane">Sophie Amrane</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Seng, Piseth" sort="Seng, Piseth" uniqKey="Seng P" first="Piseth" last="Seng">Piseth Seng</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Hocquart, Marie" sort="Hocquart, Marie" uniqKey="Hocquart M" first="Marie" last="Hocquart">Marie Hocquart</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Eldin, Carole" sort="Eldin, Carole" uniqKey="Eldin C" first="Carole" last="Eldin">Carole Eldin</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation><country 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type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Vieira, Vera Esteves" sort="Vieira, Vera Esteves" uniqKey="Vieira V" first="Vera Esteves" last="Vieira">Vera Esteves Vieira</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Tissot Dupont, Herve Tissot" sort="Tissot Dupont, Herve Tissot" uniqKey="Tissot Dupont H" first="Hervé Tissot" last="Tissot-Dupont">Hervé Tissot Tissot-Dupont</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Honore, Stephane" sort="Honore, Stephane" uniqKey="Honore S" first="Stéphane" last="Honoré">Stéphane Honoré</name><affiliation wicri:level="4"><nlm:affiliation>Service de Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Stein, Andreas" sort="Stein, Andreas" uniqKey="Stein A" first="Andreas" last="Stein">Andreas Stein</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Million, Matthieu" sort="Million, Matthieu" uniqKey="Million M" first="Matthieu" last="Million">Matthieu Million</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="La Scola, Bernard" sort="La Scola, Bernard" uniqKey="La Scola B" first="Bernard" last="La Scola">Bernard La Scola</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Veit, Veronique" sort="Veit, Veronique" uniqKey="Veit V" first="Véronique" last="Veit">Véronique Veit</name><affiliation wicri:level="1"><nlm:affiliation>Assistance Publique de Marseille, Médecine Interne, Unité de Médecine Aigue Polyvalente (UMAP), France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique de Marseille, Médecine Interne, Unité de Médecine Aigue Polyvalente (UMAP)</wicri:regionArea><wicri:noRegion>Unité de Médecine Aigue Polyvalente (UMAP)</wicri:noRegion><wicri:noRegion>Unité de Médecine Aigue Polyvalente (UMAP)</wicri:noRegion></affiliation></author><author><name sortKey="Jacquier, Alexis" sort="Jacquier, Alexis" uniqKey="Jacquier A" first="Alexis" last="Jacquier">Alexis Jacquier</name><affiliation wicri:level="4"><nlm:affiliation>Department of Radiology and Cardiovascular Imaging, Aix-Marseille Université, UMR 7339, CNRS, CRMBM-CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d'Exploration Métaboliques par Résonance Magnétique), France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Radiology and Cardiovascular Imaging, Aix-Marseille Université, UMR 7339, CNRS, CRMBM-CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d'Exploration Métaboliques par Résonance Magnétique)</wicri:regionArea><wicri:noRegion>CRMBM-CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d'Exploration Métaboliques par Résonance Magnétique)</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Deharo, Jean Claude" sort="Deharo, Jean Claude" uniqKey="Deharo J" first="Jean-Claude" last="Deharo">Jean-Claude Deharo</name><affiliation wicri:level="4"><nlm:affiliation>Assistance Publique de Marseille, Hôpital Timone, Cardiologie, Rythomologie, Aix Marseille Université, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique de Marseille, Hôpital Timone, Cardiologie, Rythomologie, Aix Marseille Université</wicri:regionArea><wicri:noRegion>Aix Marseille Université</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Drancourt, Michel" sort="Drancourt, Michel" uniqKey="Drancourt M" first="Michel" last="Drancourt">Michel Drancourt</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Fournier, Pierre Edouard" sort="Fournier, Pierre Edouard" uniqKey="Fournier P" first="Pierre Edouard" last="Fournier">Pierre Edouard Fournier</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Brouqui, Philippe" sort="Brouqui, Philippe" uniqKey="Brouqui P" first="Philippe" last="Brouqui">Philippe Brouqui</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. Electronic address: didier.raoult@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020 Mar - Apr</date><idno type="RBID">pubmed:32289548</idno><idno type="pmid">32289548</idno><idno type="doi">10.1016/j.tmaid.2020.101663</idno><idno type="pmc">PMC7151271</idno><idno type="wicri:Area/Main/Corpus">001732</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001732</idno><idno type="wicri:Area/Main/Curation">001732</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001732</idno><idno type="wicri:Area/Main/Exploration">001732</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.</title><author><name sortKey="Gautret, Philippe" sort="Gautret, Philippe" uniqKey="Gautret P" first="Philippe" last="Gautret">Philippe Gautret</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Lagier, Jean Christophe" sort="Lagier, Jean Christophe" uniqKey="Lagier J" first="Jean-Christophe" last="Lagier">Jean-Christophe Lagier</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Parola, Philippe" sort="Parola, Philippe" uniqKey="Parola P" first="Philippe" last="Parola">Philippe Parola</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Hoang, Van Thuan" sort="Hoang, Van Thuan" uniqKey="Hoang V" first="Van Thuan" last="Hoang">Van Thuan Hoang</name><affiliation wicri:level="1"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh</wicri:regionArea><wicri:noRegion>Thai Binh</wicri:noRegion></affiliation></author><author><name sortKey="Meddeb, Line" sort="Meddeb, Line" uniqKey="Meddeb L" first="Line" last="Meddeb">Line Meddeb</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Sevestre, Jacques" sort="Sevestre, Jacques" uniqKey="Sevestre J" first="Jacques" last="Sevestre">Jacques Sevestre</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Mailhe, Morgane" sort="Mailhe, Morgane" uniqKey="Mailhe M" first="Morgane" last="Mailhe">Morgane Mailhe</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Doudier, Barbara" sort="Doudier, Barbara" uniqKey="Doudier B" first="Barbara" last="Doudier">Barbara Doudier</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Aubry, Camille" sort="Aubry, Camille" uniqKey="Aubry C" first="Camille" last="Aubry">Camille Aubry</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Amrane, Sophie" sort="Amrane, Sophie" uniqKey="Amrane S" first="Sophie" last="Amrane">Sophie Amrane</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Seng, Piseth" sort="Seng, Piseth" uniqKey="Seng P" first="Piseth" last="Seng">Piseth Seng</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Hocquart, Marie" sort="Hocquart, Marie" uniqKey="Hocquart M" first="Marie" last="Hocquart">Marie Hocquart</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Eldin, Carole" sort="Eldin, Carole" uniqKey="Eldin C" first="Carole" last="Eldin">Carole Eldin</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Finance, Julie" sort="Finance, Julie" uniqKey="Finance J" first="Julie" last="Finance">Julie Finance</name><affiliation wicri:level="4"><nlm:affiliation>Assistance Publique de Marseille, Hôpital Nord, Explorations Fonctionnelles Respiratories, Aix Marseille Université, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique de Marseille, Hôpital Nord, Explorations Fonctionnelles Respiratories, Aix Marseille Université</wicri:regionArea><wicri:noRegion>Aix Marseille Université</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Vieira, Vera Esteves" sort="Vieira, Vera Esteves" uniqKey="Vieira V" first="Vera Esteves" last="Vieira">Vera Esteves Vieira</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Tissot Dupont, Herve Tissot" sort="Tissot Dupont, Herve Tissot" uniqKey="Tissot Dupont H" first="Hervé Tissot" last="Tissot-Dupont">Hervé Tissot Tissot-Dupont</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Honore, Stephane" sort="Honore, Stephane" uniqKey="Honore S" first="Stéphane" last="Honoré">Stéphane Honoré</name><affiliation wicri:level="4"><nlm:affiliation>Service de Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Stein, Andreas" sort="Stein, Andreas" uniqKey="Stein A" first="Andreas" last="Stein">Andreas Stein</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Million, Matthieu" sort="Million, Matthieu" uniqKey="Million M" first="Matthieu" last="Million">Matthieu Million</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="La Scola, Bernard" sort="La Scola, Bernard" uniqKey="La Scola B" first="Bernard" last="La Scola">Bernard La Scola</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Veit, Veronique" sort="Veit, Veronique" uniqKey="Veit V" first="Véronique" last="Veit">Véronique Veit</name><affiliation wicri:level="1"><nlm:affiliation>Assistance Publique de Marseille, Médecine Interne, Unité de Médecine Aigue Polyvalente (UMAP), France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique de Marseille, Médecine Interne, Unité de Médecine Aigue Polyvalente (UMAP)</wicri:regionArea><wicri:noRegion>Unité de Médecine Aigue Polyvalente (UMAP)</wicri:noRegion><wicri:noRegion>Unité de Médecine Aigue Polyvalente (UMAP)</wicri:noRegion></affiliation></author><author><name sortKey="Jacquier, Alexis" sort="Jacquier, Alexis" uniqKey="Jacquier A" first="Alexis" last="Jacquier">Alexis Jacquier</name><affiliation wicri:level="4"><nlm:affiliation>Department of Radiology and Cardiovascular Imaging, Aix-Marseille Université, UMR 7339, CNRS, CRMBM-CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d'Exploration Métaboliques par Résonance Magnétique), France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Radiology and Cardiovascular Imaging, Aix-Marseille Université, UMR 7339, CNRS, CRMBM-CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d'Exploration Métaboliques par Résonance Magnétique)</wicri:regionArea><wicri:noRegion>CRMBM-CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d'Exploration Métaboliques par Résonance Magnétique)</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Deharo, Jean Claude" sort="Deharo, Jean Claude" uniqKey="Deharo J" first="Jean-Claude" last="Deharo">Jean-Claude Deharo</name><affiliation wicri:level="4"><nlm:affiliation>Assistance Publique de Marseille, Hôpital Timone, Cardiologie, Rythomologie, Aix Marseille Université, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique de Marseille, Hôpital Timone, Cardiologie, Rythomologie, Aix Marseille Université</wicri:regionArea><wicri:noRegion>Aix Marseille Université</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Drancourt, Michel" sort="Drancourt, Michel" uniqKey="Drancourt M" first="Michel" last="Drancourt">Michel Drancourt</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Fournier, Pierre Edouard" sort="Fournier, Pierre Edouard" uniqKey="Fournier P" first="Pierre Edouard" last="Fournier">Pierre Edouard Fournier</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Brouqui, Philippe" sort="Brouqui, Philippe" uniqKey="Brouqui P" first="Philippe" last="Brouqui">Philippe Brouqui</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. Electronic address: didier.raoult@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></analytic><series><title level="j">Travel medicine and infectious disease</title><idno type="eISSN">1873-0442</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Azithromycin (therapeutic use)</term><term>Betacoronavirus (drug effects)</term><term>Coronavirus Infections (drug therapy)</term><term>Drug Therapy, Combination (MeSH)</term><term>Female (MeSH)</term><term>France (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (therapeutic use)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Nasopharynx (virology)</term><term>Pandemics (MeSH)</term><term>Pilot Projects (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term><term>Viral Load (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Association de médicaments (MeSH)</term><term>Azithromycine (usage thérapeutique)</term><term>Betacoronavirus (effets des médicaments et des substances chimiques)</term><term>Charge virale (MeSH)</term><term>Femelle (MeSH)</term><term>France (MeSH)</term><term>Humains (MeSH)</term><term>Hydroxychloroquine (usage thérapeutique)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Partie nasale du pharynx (virologie)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Projets pilotes (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Azithromycin</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Azithromycine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Partie nasale du pharynx</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Nasopharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Pilot Projects</term><term>Viral Load</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Charge virale</term><term>Femelle</term><term>France</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Projets pilotes</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>We need an effective treatment to cure COVID-19 patients and to decrease virus carriage duration.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We conducted an uncontrolled, non-comparative, observational study in a cohort of 80 relatively mildly infected inpatients treated with a combination of hydroxychloroquine and azithromycin over a period of at least three days, with three main measurements: clinical outcome, contagiousness as assessed by PCR and culture, and length of stay in infectious disease unit (IDU).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>All patients improved clinically except one 86 year-old patient who died, and one 74 year-old patient still in intensive care. A rapid fall of nasopharyngeal viral load was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% of patients at Day5. Consequently patients were able to be rapidly discharged from IDU with a mean length of stay of five days.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>We believe there is urgency to evaluate the effectiveness of this potentially-life saving therapeutic strategy at a larger scale, both to treat and cure patients at an early stage before irreversible severe respiratory complications take hold and to decrease duration of carriage and avoid the spread of the disease. Furthermore, the cost of treatment is negligible.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32289548</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>18</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-0442</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><PubDate><MedlineDate>2020 Mar - Apr</MedlineDate></PubDate></JournalIssue><Title>Travel medicine and infectious disease</Title><ISOAbbreviation>Travel Med Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.</ArticleTitle><Pagination><MedlinePgn>101663</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1477-8939(20)30131-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.tmaid.2020.101663</ELocationID><Abstract><AbstractText Label="BACKGROUND">We need an effective treatment to cure COVID-19 patients and to decrease virus carriage duration.</AbstractText><AbstractText Label="METHODS">We conducted an uncontrolled, non-comparative, observational study in a cohort of 80 relatively mildly infected inpatients treated with a combination of hydroxychloroquine and azithromycin over a period of at least three days, with three main measurements: clinical outcome, contagiousness as assessed by PCR and culture, and length of stay in infectious disease unit (IDU).</AbstractText><AbstractText Label="RESULTS">All patients improved clinically except one 86 year-old patient who died, and one 74 year-old patient still in intensive care. A rapid fall of nasopharyngeal viral load was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% of patients at Day5. Consequently patients were able to be rapidly discharged from IDU with a mean length of stay of five days.</AbstractText><AbstractText Label="CONCLUSION">We believe there is urgency to evaluate the effectiveness of this potentially-life saving therapeutic strategy at a larger scale, both to treat and cure patients at an early stage before irreversible severe respiratory complications take hold and to decrease duration of carriage and avoid the spread of the disease. Furthermore, the cost of treatment is negligible.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gautret</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lagier</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parola</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoang</LastName><ForeName>Van Thuan</ForeName><Initials>VT</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meddeb</LastName><ForeName>Line</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sevestre</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mailhe</LastName><ForeName>Morgane</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doudier</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aubry</LastName><ForeName>Camille</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amrane</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seng</LastName><ForeName>Piseth</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hocquart</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eldin</LastName><ForeName>Carole</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Finance</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Assistance Publique de Marseille, Hôpital Nord, Explorations Fonctionnelles Respiratories, Aix Marseille Université, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vieira</LastName><ForeName>Vera Esteves</ForeName><Initials>VE</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tissot-Dupont</LastName><ForeName>Hervé Tissot</ForeName><Initials>HT</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Honoré</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service de Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stein</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Million</LastName><ForeName>Matthieu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colson</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>La Scola</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veit</LastName><ForeName>Véronique</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Assistance Publique de Marseille, Médecine Interne, Unité de Médecine Aigue Polyvalente (UMAP), France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacquier</LastName><ForeName>Alexis</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Radiology and Cardiovascular Imaging, Aix-Marseille Université, UMR 7339, CNRS, CRMBM-CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d'Exploration Métaboliques par Résonance Magnétique), France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deharo</LastName><ForeName>Jean-Claude</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Assistance Publique de Marseille, Hôpital Timone, Cardiologie, Rythomologie, Aix Marseille Université, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drancourt</LastName><ForeName>Michel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fournier</LastName><ForeName>Pierre Edouard</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rolain</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brouqui</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raoult</LastName><ForeName>Didier</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. Electronic address: didier.raoult@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Travel Med Infect Dis</MedlineTA><NlmUniqueID>101230758</NlmUniqueID><ISSNLinking>1477-8939</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>83905-01-5</RegistryNumber><NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Infect Control Hosp Epidemiol. 2020 Sep;41(9):1108-1110</RefSource><PMID Version="1">32290883</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Ann Rheum Dis. 2020 Jun;79(6):734-736</RefSource><PMID Version="1">32295786</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Med Sci (Paris). 2020 May;36(5):521-523</RefSource><PMID Version="1">32452375</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017963" MajorTopicYN="N">Azithromycin</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Azithromycin</Keyword><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Culture</Keyword><Keyword MajorTopicYN="Y">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="Y">PCR</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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IdType="pubmed">32145363</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Glob Health. 2020 May;8(5):e639-e640</Citation><ArticleIdList><ArticleId IdType="pubmed">32199468</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>France</li><li>Viêt Nam</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement><orgName><li>Université d'Aix-Marseille</li></orgName></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Gautret, Philippe" sort="Gautret, Philippe" uniqKey="Gautret P" first="Philippe" last="Gautret">Philippe Gautret</name></region><name sortKey="Amrane, Sophie" sort="Amrane, Sophie" uniqKey="Amrane S" first="Sophie" last="Amrane">Sophie Amrane</name><name sortKey="Aubry, Camille" sort="Aubry, Camille" uniqKey="Aubry C" first="Camille" last="Aubry">Camille Aubry</name><name sortKey="Brouqui, Philippe" sort="Brouqui, Philippe" uniqKey="Brouqui P" first="Philippe" last="Brouqui">Philippe Brouqui</name><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><name sortKey="Deharo, Jean Claude" sort="Deharo, Jean Claude" uniqKey="Deharo J" first="Jean-Claude" last="Deharo">Jean-Claude Deharo</name><name sortKey="Doudier, Barbara" sort="Doudier, Barbara" uniqKey="Doudier B" first="Barbara" last="Doudier">Barbara Doudier</name><name sortKey="Drancourt, Michel" sort="Drancourt, Michel" uniqKey="Drancourt M" first="Michel" last="Drancourt">Michel Drancourt</name><name sortKey="Eldin, Carole" sort="Eldin, Carole" uniqKey="Eldin C" first="Carole" last="Eldin">Carole Eldin</name><name sortKey="Finance, Julie" sort="Finance, Julie" uniqKey="Finance J" first="Julie" last="Finance">Julie Finance</name><name sortKey="Fournier, Pierre Edouard" sort="Fournier, Pierre Edouard" uniqKey="Fournier P" first="Pierre Edouard" last="Fournier">Pierre Edouard Fournier</name><name sortKey="Hocquart, Marie" sort="Hocquart, Marie" uniqKey="Hocquart M" first="Marie" last="Hocquart">Marie Hocquart</name><name sortKey="Honore, Stephane" sort="Honore, Stephane" uniqKey="Honore S" first="Stéphane" last="Honoré">Stéphane Honoré</name><name sortKey="Jacquier, Alexis" sort="Jacquier, Alexis" uniqKey="Jacquier A" first="Alexis" last="Jacquier">Alexis Jacquier</name><name sortKey="La Scola, Bernard" sort="La Scola, Bernard" uniqKey="La Scola B" first="Bernard" last="La Scola">Bernard La Scola</name><name sortKey="Lagier, Jean Christophe" sort="Lagier, Jean Christophe" uniqKey="Lagier J" first="Jean-Christophe" last="Lagier">Jean-Christophe Lagier</name><name sortKey="Mailhe, Morgane" sort="Mailhe, Morgane" uniqKey="Mailhe M" first="Morgane" last="Mailhe">Morgane Mailhe</name><name sortKey="Meddeb, Line" sort="Meddeb, Line" uniqKey="Meddeb L" first="Line" last="Meddeb">Line Meddeb</name><name sortKey="Million, Matthieu" sort="Million, Matthieu" uniqKey="Million M" first="Matthieu" last="Million">Matthieu Million</name><name sortKey="Parola, Philippe" sort="Parola, Philippe" uniqKey="Parola P" first="Philippe" last="Parola">Philippe Parola</name><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><name sortKey="Seng, Piseth" sort="Seng, Piseth" uniqKey="Seng P" first="Piseth" last="Seng">Piseth Seng</name><name sortKey="Sevestre, Jacques" sort="Sevestre, Jacques" uniqKey="Sevestre J" first="Jacques" last="Sevestre">Jacques Sevestre</name><name sortKey="Stein, Andreas" sort="Stein, Andreas" uniqKey="Stein A" first="Andreas" last="Stein">Andreas Stein</name><name sortKey="Tissot Dupont, Herve Tissot" sort="Tissot Dupont, Herve Tissot" uniqKey="Tissot Dupont H" first="Hervé Tissot" last="Tissot-Dupont">Hervé Tissot Tissot-Dupont</name><name sortKey="Veit, Veronique" sort="Veit, Veronique" uniqKey="Veit V" first="Véronique" last="Veit">Véronique Veit</name><name sortKey="Vieira, Vera Esteves" sort="Vieira, Vera Esteves" uniqKey="Vieira V" first="Vera Esteves" last="Vieira">Vera Esteves Vieira</name></country><country name="Viêt Nam"><noRegion><name sortKey="Hoang, Van Thuan" sort="Hoang, Van Thuan" uniqKey="Hoang V" first="Van Thuan" last="Hoang">Van Thuan Hoang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000016 | SxmlIndent | more
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|wiki= Sante
|area= CovidFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32289548
|texte= Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
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